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Sulfonylureas are a group of medications used to treat Diabetes (type 2 diabetes). Sulfonylureas help to increase the release of insulin from the pancreas. The first Sulfonylureas were used in the 1950s.
Some of the popular sulfonylureas often prescribed are -
Sulfonylureas were firstly discovered, in 1942, by the chemist Marcel Janbon and his co-workers. They were studying sulfonamide antibiotics and discovered the compound sulfonylureas for treating hypoglycemia in animals. Later on, in the 1950s sulfonylureas were developed for treating diabetes.
Sulfonylureas(organic compounds) bind to and close ATP-sensitive K+ channels on the cell membrane of pancreatic beta cells, which depolarizes the cell by preventing the exiting of potassium. This depolarization opens voltage-gated channels. The rise in intracellular calcium accelerates the fusion of insulin granules with the cell membrane and therefore increased the flow of mature insulin.
There is some evidence that sulfonylureas also sensitize β-cells to glucose, that they limit the production of glucose in the liver, that they decrease the breakdown and release of fatty acids by adipose, and decrease the clearance of insulin by the liver.
Furthermore, it has been shown that sulfonylureas interact with the nucleotide exchange factor which has a decreased glucose-lowering effect upon sulfonylurea treatment.
Sulfonylureas are oral(taken from the mouth directly) medications that help lower blood glucose levels in people living with Type 2 diabetes. All sulfonylureas are available in generic versions, making the sulfonylureas relatively affordable. The main side effect of sulfonylureas is hypoglycemia(low blood sugar level). The chances of hypoglycemia increase when sulfonylureas are combined with other diabetes medications, like metformin or insulin.
We Specialty Care Clinics help you to understand the mechanism of sulfonylureas and provide you with the best medications for diabetes and the best outcome from the medications. If anyone of you has diabetes or need consultation on the uses of sulfonylureas, connect with us at 469-545-9983